Text Box: Newsletter
Abreast Of  Ear, Nose & Throat / Head & Neck Advances
28 January,  2006
 
Hello, All. Welcome to this week's ORL Update. I do hope you find my picks for this week exciting and useful
 
Biodun Olusesi, Newsletter Editor
Mitomycin C and Canal Atresia.......

Mitomycin C, the anti-tumor antibiotics whose use beyond oncological indications is expanding to several aspect of perplexing otorhinolaryngological conditions including prevention of restenosis in choanal atresia, laryngeal and tracheal stenosis, and bronchial stenosis, has just been reported again to show promises in preventing restenosis following surgery for fibrotic ear canal atresia, according to a recent report by Battelino, Hocevar-Boltezar & Zargi (Ear Nose Throat J. 2005 Dec;84(12):776-9)
 

Abstract: The ability of mitomycin C to inhibit fibroblasts in vitro has prompted its use during standard surgical procedures as a means of preventing the development of adhesions and stenosis. We conducted a prospective study to evaluate the effectiveness of topical mitomycin C in maintaining an open external auditory canal in 6 ears of 4 patients with aural fibrotic atresia who were undergoing meatoplasty. During the procedure, we applied 1 ml of mitomycin C (0.4 mg/ml) for 4 minutes to the external auditory canal (in 1 case, mitomycin C was reapplied to an ear 1 month later). Between 3 and 14 months postoperatively, the patency of the ear canal was assessed visually and hearing was evaluated audiometrically. Adequate patency was achieved in 5 of the 6 ears (83.3%), and the air-bone gap in these 5 ears had improved to 10 dB or less. No postoperative complications or sensorineural hearing loss was observed. In this very limited number of cases, we found that the intraoperative use of mitomycin C appeared to have been helpful in preventing scarring in both congenital and secondary fibrotic atresias of the external auditory canal. These preliminary results are encouraging, and a prospective, placebo-controlled study appears to be warranted.
 

 
TOP PICKS

Re-exploring Bekesy or what...?
After over four decades since the Hungarian physicist, Georg von Bekesy was awarded the nobel prize for practical demonstration of the functionality of the human cochlea, the cochlea model he highlighted in his nobel lecture, will appear quite crude compared to that recently described by  Wittbrodt, Steele & Puria (Audiology and Neurotology 2006;11:104-112) from Stanford had just reported developing a physical model of the human cochlea.

Abstract: Advances in micromachining technology have provided the opportunity to explore possibilities of creating life-sized physical models of the cochlea. The physical model of the cochlea consists of two fluid-filled channels separated by an elastic partition. The partition is micro machined from silicon and uses a 36-mm linearly tapered polyimide plate with a width of 100 µm at the basal end and 500 µm at the apex to represent the basilar membrane. Thicknesses from 1 to 5 µm have been fabricated. Discrete aluminum fibers (1.5 µm in width) are machined to create direction-dependent properties. A 0.5 × 0.5 mm opening represents the helicotrema. The fluid channels are machined from plexiglas using conventional machining methods. A magnet-coil system excites the fluid channel. Measurements on a model with thickness 4.75 µm show a velocity gain of 4 and phase of 3.5 radians at a location 23 mm from the base. Mathematical modeling using a 3-D formulation confirm the general characteristics of the measured response.
 


Coming Events of Importance to Otolaryngologists in Africa...
 

  1. BRITISH ACADEMIC CONFERENCE IN OTOLARYNGOLOGY - Humanitarian Award, 2006. For Details click HERE

  2. Annual West Africa College of Surgeons Conference, Accra, Ghana, Feb 2006.
  3. Association of Paediatric Otolaryngologists of India 12th Annual Conference and CME in Paediatric Otolaryngology
    February 25-26, 2006; New Delhi, India
  4. 8th International Otology Course of the Jean Causse Ear Clinic
    June 22-24, 2006; Béziers, France
  5. 110th American Academy of ORL,Head & Neck Surgery Annual Meeting & OTO EXPO
    September 17-20, 2006;
    Toronto, Canada.
  6. 42nd South African ENT Congress joint meeting with the British Association of Otolaryngology - Head & Neck Surgery
    October 29-November 1, 2006;
    Cape Town, South Africa.

         For more Worldwide otolaryngological events and conferences....Click Here


Predicting the reliability of behavioural audiometry.....?       

If you are concerned about what to make of the variability of response obtained with behavioural audiometry, then you may be interested in this report by Han et al (ORL 2006;68:64-68) from China reporting that the auditory steady state response (ASSR) is a good tool to predict behavioral hearing thresholds.

Text Box: Previous Newsletter
Abstract: Objective: It was the aim of this study to explore the use of auditory steady-state response (ASSR) to multiple simultaneous stimuli for threshold estimation in young children. Method: The subjects consisted of 40 children, aged from 6 months to 5 years, with variant degrees of sensorineural hearing loss. Simultaneous tonepips (0.5, 1, 2 and 4 kHz) with an amplitude modulated at different rates from 77 to 103 Hz were presented to both ears by insert phones. All children were tested with ASSR and age-appropriate behavioral tests. Results: We found that (1) ASSR thresholds were usually higher than behavioral thresholds with a difference of 8-15 dB, (2) the behavioral thresholds were significantly correlated with ASSR thresholds (p = 0.000), and (3) there was a great difference between ASSR thresholds and behavioral thresholds found in a child with auditory neuropathy. Conclusion: Being objective, frequency specific and well correlated with behavioral thresholds, ASSR to multiple simultaneous stimuli was proven to be a good tool to predict behavioral hearing thresholds

 

 

 
Case Review
 
CLINICAL RADIOGRAPH OF THE WEEK

An 51-year old female presented with 3-year history of recurrent right tinnitus and otalgia. She also experiences slight hearing loss on the right, but no other local or systemic symptoms.  Otoscopy revealed a reddish spot on the Right TM which appeared to fluctuate in size according to previous follow up case note documentation. The MRI brain revealed the feature arrowed on this picture.

 

What is the diagnosis?

  • Parting Shot...
    If you have an interesting case to discuss or share with other Otolaryngologists all over Africa, feel free to email Me or at best go to otolaryngology in Africa blogsite and post your case
  • Also, if you are among those who requested for a copy of DODA at the last ORLSON Meeting @ Port Harcourt, please take time to view the DODA - FAQ page, and expect your copy anytime now. The program has been mailed to you.
  • An online video demonstration of doda is available at http://www.otolaryngologyinafrica.net/doda_video.htm  This video takes about 30 - 45 minutes to fully load on a broad band network the first time, but once fully loaded could be viewed over and over again
  • It appears as if the website of ORLSON - http://www.orlson.org/  is no longer active or visible on the web! Please For a list of active web sites of otolaryngological societies in Africa, click HERE
  • If you have anything you want to communicate with other Otolaryngologists - news, request, etc, feel free to email your communication to orl-mailer@ otolaryngologyinafrica.net. Your request will appear in member's page soon to be created.
  • Reviewers wanted for otolaryngology news journals watch page. If you are an Otolaryngologist in Africa and will like to be our journal reviewer, please feel free to email orl-mailer@otolaryngologyinafrica.net

Till Next Week,

Biodun


 

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