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Abreast Of Ear, Nose &
Throat / Head & Neck Advances
28 January, 2006
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Hello, All. Welcome
to this week's ORL Update. I do hope you find my picks
for this week exciting and useful |
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Biodun Olusesi,
Newsletter Editor |
Mitomycin C and Canal Atresia.......
Mitomycin C, the anti-tumor
antibiotics whose use beyond oncological
indications is expanding to several aspect of
perplexing otorhinolaryngological conditions
including prevention of restenosis in choanal
atresia, laryngeal and tracheal stenosis, and
bronchial stenosis, has just been reported again
to show promises in preventing restenosis
following surgery for fibrotic ear canal atresia,
according to a recent report by
Battelino, Hocevar-Boltezar & Zargi (Ear
Nose Throat J.
2005 Dec;84(12):776-9)
Abstract: The ability of mitomycin C
to inhibit fibroblasts in vitro has prompted its
use during standard surgical procedures as a means
of preventing the development of adhesions and
stenosis. We conducted a prospective study to
evaluate the effectiveness of topical mitomycin C
in maintaining an open external auditory canal in
6 ears of 4 patients with aural fibrotic atresia
who were undergoing meatoplasty. During the
procedure, we applied 1 ml of mitomycin C (0.4
mg/ml) for 4 minutes to the external auditory
canal (in 1 case, mitomycin C was reapplied to an
ear 1 month later). Between 3 and 14 months
postoperatively, the patency of the ear canal was
assessed visually and hearing was evaluated
audiometrically. Adequate patency was achieved in
5 of the 6 ears (83.3%), and the air-bone gap in
these 5 ears had improved to 10 dB or less. No
postoperative complications or sensorineural
hearing loss was observed. In this very limited
number of cases, we found that the intraoperative
use of mitomycin C appeared to have been helpful
in preventing scarring in both congenital and
secondary fibrotic atresias of the external
auditory canal. These preliminary results are
encouraging, and a prospective, placebo-controlled
study appears to be warranted.
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TOP PICKS
Re-exploring
Bekesy or what...?
After over four decades since the Hungarian physicist,
Georg von Bekesy was awarded the nobel prize for
practical demonstration of the functionality of the
human cochlea, the cochlea model he highlighted in his
nobel lecture, will appear quite crude
compared to that recently described by Wittbrodt, Steele & Puria (Audiology
and Neurotology
2006;11:104-112) from Stanford had just
reported developing a physical model of the human
cochlea.
Abstract: Advances in micromachining
technology have provided the opportunity to explore
possibilities of creating life-sized physical models of
the cochlea. The physical model of the cochlea consists
of two fluid-filled channels separated by an elastic
partition. The partition is micro machined from silicon
and uses a 36-mm linearly tapered polyimide plate with a
width of 100 µm at the basal end and 500 µm at the apex
to represent the basilar membrane. Thicknesses from 1 to
5 µm have been fabricated. Discrete aluminum fibers (1.5
µm in width) are machined to create direction-dependent
properties. A 0.5 × 0.5 mm opening represents the
helicotrema. The fluid channels are machined from
plexiglas using conventional machining methods. A
magnet-coil system excites the fluid channel.
Measurements on a model with thickness 4.75 µm show a
velocity gain of 4 and phase of 3.5 ∩
radians at a location 23 mm from the base. Mathematical
modeling using a 3-D formulation confirm the general
characteristics of the measured response.
Coming Events of Importance to Otolaryngologists in
Africa...
-
BRITISH
ACADEMIC CONFERENCE IN OTOLARYNGOLOGY - Humanitarian
Award, 2006. For Details
click
HERE
- Annual West Africa
College of Surgeons Conference, Accra, Ghana, Feb
2006.
-
Association of Paediatric Otolaryngologists of
India 12th Annual Conference and CME in Paediatric
Otolaryngology
February 25-26, 2006; New Delhi, India
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8th International Otology Course of the Jean Causse
Ear Clinic
June 22-24, 2006; Béziers, France
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110th American Academy of ORL,Head & Neck Surgery
Annual Meeting & OTO EXPO
September 17-20, 2006;
Toronto, Canada.
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42nd South African ENT Congress joint meeting with
the British Association of Otolaryngology - Head &
Neck Surgery
October 29-November 1, 2006;
Cape Town, South Africa.
For more Worldwide otolaryngological events and conferences....Click
Here
Predicting the reliability of behavioural
audiometry.....?
If you are concerned about what to make of the
variability of response obtained with behavioural
audiometry, then you may be interested in this report by
Han et al (ORL
2006;68:64-68) from China reporting that
the auditory steady state response (ASSR) is a good tool
to predict behavioral hearing thresholds.
Abstract:
Objective: It was the aim of this study to
explore the use of auditory steady-state response (ASSR)
to multiple simultaneous stimuli for threshold
estimation in young children. Method: The
subjects consisted of 40 children, aged from 6 months to
5 years, with variant degrees of sensorineural hearing
loss. Simultaneous tonepips (0.5, 1, 2 and 4 kHz) with
an amplitude modulated at different rates from 77 to 103
Hz were presented to both ears by insert phones. All
children were tested with ASSR and age-appropriate
behavioral tests. Results: We found that (1) ASSR
thresholds were usually higher than behavioral
thresholds with a difference of 8-15 dB, (2) the
behavioral thresholds were significantly correlated with
ASSR thresholds (p = 0.000), and (3) there was a great
difference between ASSR thresholds and behavioral
thresholds found in a child with auditory neuropathy.
Conclusion: Being objective, frequency specific and
well correlated with behavioral thresholds, ASSR to
multiple simultaneous stimuli was proven to be a good
tool to predict behavioral hearing thresholds
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CLINICAL RADIOGRAPH OF THE
WEEK |
An
51-year old female presented with 3-year history
of recurrent right tinnitus and otalgia.
She also experiences slight hearing loss on the
right, but no other local or systemic symptoms.
Otoscopy revealed a reddish spot on the Right TM
which appeared to fluctuate in size according to
previous follow up case note documentation. The
MRI brain revealed the feature arrowed on this
picture.
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What is the diagnosis?
- Parting Shot...
If you have an interesting
case to discuss or share with other Otolaryngologists
all over Africa, feel free to email
Me or at best go to
otolaryngology in Africa blogsite
and post your case
- Also, if you are among those who requested for a copy
of DODA at the last ORLSON Meeting @ Port Harcourt,
please take time to view the
DODA - FAQ page,
and expect your copy anytime now. The program has been
mailed to you.
- An online video demonstration of doda is available
at
http://www.otolaryngologyinafrica.net/doda_video.htm
This
video takes about 30 - 45 minutes to fully load on a
broad band network the first time, but once fully
loaded could be viewed over and over again
- It appears as if the website of ORLSON -
http://www.orlson.org/ is no longer active
or visible on the web! Please For a list of active web
sites of otolaryngological societies in Africa, click
HERE
- If you have anything you want to communicate with
other Otolaryngologists - news, request, etc, feel
free to email your communication to
orl-mailer@
otolaryngologyinafrica.net.
Your request will appear in member's page soon to be
created.
- Reviewers wanted for otolaryngology news journals
watch page. If you are an Otolaryngologist in Africa
and will like to be our journal reviewer, please feel
free to email
orl-mailer@otolaryngologyinafrica.net
Till Next Week,
Biodun
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© Copyright Dr 'Biodun
Olusesi,
2005 - 2006 |